Table 3 Results of ANCOVA analyses for anxiety and distress levels between timepoints and each covariate added separately

Variable

B

SE

95%-CI

B

SE

95%-CI

B

SE

95%-CI

B

SE

95%-CI

Gender (male (0), female (1))

3.25

0.78

1.71; 4.78

1.42

0.69

0.05; 2.79

1.21

0.40

0.42; 1.99

0.86

0.49

-0.10; 1.82

Age

P < 0.001

P < 0.001

P = 0.001

P < 0.001

  < 23 years

Ref

Ref

Ref

Ref

 23.1–27.5 years

0.69

1.13

-1.54; 2.91

0.87

0.88

-0.87; 2.60

0.68

0.57

-0.45; 1.80

0.41

0.64

-0.87; 1.68

 27.5–34.5 years

0.95

1.11

-1.24; 3.13

-0.75

0.88

-2.50; 1.00

0.59

0.56

-0.52; 1.70

-0.27

0.64

-1.56; 1.01

 34.6 > years

-0.60

1.11

-2.79; 1.58

0.39

0.95

-1.48; 2.25

-0.14

0.56

-1.25; 0.97

0.37

0.68

-0.98; 1.72

PrEP (yes (1), no(0))

2.12

0.86

0.43; 3.81

-0.72

0.70

-2.10; 0.66

1.16

0.43

0.31; 2.02

-0.48

0.51

-1.49; 0.54

Type of injury

P < 0.001

 Type I

Ref

Ref

Ref

Ref

 Type II

-2.39

1.71

-5.78; 0.99

-3.09

2.29

-7.62; 1.44

-0.32

0.97

-2.23; 1.59

-3.98

2.00

-7.94; -0.02

 Type III

-2.38

1.60

-5.55; 0.78

-2.59

2.24

-7.01; 1.83

-0.37

0.91

-2.17; 1.43

-4.00

1.97

-7.90; -0.10

Risk awareness T1 (yes (1), no(0))

2.14

0.91

0.34; 3.93

-0.28

0.78

-1.82; 1.26

0.69

0.46

-0.22; 1.61

-0.21

0.56

-1.32; 0.91

Unexpected AAI (yes (1), no(0))

-0.73

1.32

-3.34; 1.88

1.79

1.05

-0.29; 3.87

0.04

0.67

-1.29; 1.36

0.90

0.82

-0.72; 2.51

Delay PEP

P < 0.001

P < 0.001

P < 0.001

P < 0.001

  < 24 h

Ref

Ref

Ref

Ref

 24 h – 48 h

1.01

1.06

-1.09; 3.10

-0.78

0.79

-2.34; 0.78

0.59

0.51

-0.42; 1.59

-1.30

0.57

-2.42; -0.18

 48 h > 

-0.06

1.12

-2.27; 2.16

0.80

0.84

-0.86; 2.45

0.27

0.53

-0.79; 1.32

0.16

0.60

-1.01; 1.34

Type of animal

P < 0.001

P < 0.001

P = 0.002

P < 0.001

 Dog

Ref

Ref

Ref

Ref

 Cat

-1.07

1.08

-3.21; 1.07

0.70

0.87

-1.03; 2.42

-0.55

0.55

-1.64; 0.54

-0.56

0.65

-1.85; 0.72

 Monkey

-0.18

0.98

-2.10; 1.75

1.81

0.74

0.34; 3.28

-0.33

0.50

-1.31; 0.65

0.63

0.57

-0.49; 1.76

 Bat

-0.17

2.71

-5.51; 5.17

-2.21

2.22

-6.59; 2.17

-0.35

1.54

-3.39; 2.70

-0.31

1.99

-4.24; 3.62

 Other

-3.86

3.12

-10.02; 2.30

4.28

2.69

-1.04; 9.61

-1.84

1.54

-4.88; 1.20

1.36

2.02

-2.62; 5.35

Location of injury

P < 0.001

P < 0.001

P = 0.001

P < 0.001

 Arm/hand area

Ref

Ref

Ref

Ref

 Head/neck area

-0.91

2.10

-5.06; 3.24

-1.89

1.97

-5.78; 2.01

1.22

1.03

-3.24; 0.81

1.02

1.46

-1.86; 3.91

 Thorax

4.49

2.72

-0.87; 9.85

6.28

2.26

1.81; 10.75

2.35

1.33

-0.28; 1.18

2.34

1.67

-0.97; 1.93

 Thigh

0.43

1.40

-2.32; 3.19

-0.99

1.11

-3.18; 1.19

-0.24

0.72

-1.67; 1.18

0.26

0.84

-1.40; 1.93

 Calf/foot area

-0.20

0.88

-1.93; 1.53

0.22

0.70

-1.16; 1.59

0.14

0.44

-0.73; 1.01

0.50

0.53

-0.54; 1.54

 Other

-0.06

3.79

-7.54; 7.42

3.27

2.73

-2.13; 8.66

2.79

1.86

-0.88; 6.45

-0.25

2.03

-4.26; 3.76

Informed at T1 (yes (1), no(0))

-0.04

0.81

-1.62; 1.55

1.12

0.66

-0.19; 2.43

-0.45

0.41

-1.06; 0.56

0.86

0.48

-0.08; 1.81

Informed at T2

(yes (1), no(0))

-0.24

0.80

-1.82; 1.34

-0.11

0.59

-1.27; 1.04

Travel duration in days

0.01

0.01

-0.01; 0.02

0.00

0.01

-0.01; 0.01

0.00

0.00

-0.01; 0.01

0.00

0.00

-0.01; 0.01

WHO region

P < 0.001

P < 0.001

P < 0.001

P < 0.001

 EU

Ref

Ref

Ref

Ref

 WP

2.41

1.47

-0.48; 5.30

1.07

1.31

-1.53; 3.66

1.18

0.73

-0.27; 2.62

0.01

0.96

-1.89; 1.92

 SEA

1.54

1.25

-0.92; 4.00

2.41

1.17

0.11; 4.71

0.54

0.63

-0.69; 1.78

1.08

0.85

-0.61; 2.76

 SA

2.73

1.73

-0.68; 6.15

0.24

1.49

-2.70; 3.19

1.28

0.86

-0.42; 0.98

0.09

1.09

-2.06; 2.24

 A

5.02

1.99

1.09; 8.95

2.20

1.83

-1.43; 5.83

2.96

1.01

0.95; 4.96

0.19

1.34

-2.45; 2.83

 EM

0.38

2.14

-3.84; 4.61

2.48

1.90

-1.28; 6.25

0.96

1.06

-1.13; 3.05

1.31

1.39

-1.43; 4.06

 CA

4.86

2.40

0.13; 9.58

2.43

2.21

-1.94; 6.79

0.11

1.27

-2.40; 2.61

1.24

1.60

-1.93; 4.41

 NA

1.07

2.58

-4.01; 9.58

0.10

2.47

-4.78; 4.99

1.87

1.27

-0.64; 4.38

-0.02

1.80

-3.57; 3.54

Travelled multiple countries (yes (1), no(0))

0.21

1.32

-2.41; 2.84

0.41

0.98

-1.55; 2.36

0.57

0.61

-0.65; 1.78

0.33

0.65

-0.96; 1.63