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Table 4 Inflection points in the temporal trends of morbidity and mortality indicators for covid-19 among people aged 18 to 59 years. Brazil, 2020–22

From: Effect of vaccination against Covid-19 one year after its introduction in Brazil

Indicators

Joinpoint

EW/Year

Duration in weeks

WPC

95% IC

P-Value

Start

The end

Low

High

Hospitalization

0

8/2020

15/2020

7

145.0

124.5

167.4

 < 0.001

1

15/2020

42/2020

27

-3.5

-4.6

-2.3

 < 0.001

2

42/2020

19/2021

30

6.7

5.6

7.8

 < 0.001

3

19/2021

49/2021

30

-13.3

-14.2

-12.4

 < 0.001

4

49/2021

3/2022

6

57.8

36.3

82.7

 < 0.001

5

3/2022

13/2022

10

-33.7

-37.0

-30.2

 < 0.001

Severitya

0

8/2020

11/2020

3

17.3

7.3

28.3

0.001

1

11/2020

15/2020

4

-10.4

-18.0

-1.9

0.017

2

15/2020

49/2021

87

0.4

0.4

0.5

 < 0.001

3

49/2021

2/2022

5

-5.3

-10.5

0.2

0.060

4

2/2022

13/2022

11

1.9

0.7

3.1

0.003

Case fatality rate

0

8/2020

17/2020

9

3.7

0.4

7.1

0.028

1

17/2020

44/2020

27

-1.7

-2.3

-1.0

 < 0.001

2

44/2020

13/2021

22

3.5

2.5

4.4

 < 0.001

3

13/2021

30/2021

17

-3.2

-4.5

-1.9

 < 0.001

4

20/2021

13/2022

35

0.7

0.2

1.1

0.003

Mortality

0

8/2020

17/2020

9

183.4

161.2

207.6

 < 0.001

1

17/2020

46/2020

29

-4.3

-5.7

-2.9

 < 0.001

2

46/2020

20/2021

27

9.9

8.1

11.7

 < 0.001

3

20/2021

51/2021

31

-13.4

-14.6

-12.3

 < 0.001

4

51/2021

5/2022

6

52.5

24.8

86.3

 < 0.001

5

5/2022

13/2022

8

-27.6

-34.4

-20.2

 < 0.001

  1. aCovid-19 cases admitted to the ICU and/or who received invasive ventilatory support