Fig. 1

SARS-CoV-2 full RNA genomic schematic structure with approximately 29,700 nucleotides and S protein domains. The genome encodes two large genes ORF1a encodes (nsp1–nsp10), ORF1b encodes (nsp1–nsp16), for a total of 16 non-structural proteins (nsp1– nsp16). A replicase complex comprised by ORF1a and ORF1b at the 5′UTR region. Four structural genes encode the structural proteins, spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins, and accessory proteins included among the structural proteins, that are characteristic of SARS-CoV-2 in white. A poly (A) tail at the 3′UTR. NTD: N-Terminal Domain (14–305 residues). RBD: Receptor-Binding Domain (RBD, 319–541 residues). FP: Fusion Peptide (788–806 residues). HR1: Heptapeptide Repeat Sequence 1 (HR1) (912–984 residues). TM: Transmembrane Domain (1213–1237 residues). CT: Cytoplasm Domain (1237–1273)