From: Dynamics of dengue and SARS-COV-2 co-infection in an endemic area of Colombia
Case 1 | Case 2 | Reference value | |
---|---|---|---|
Days of symptoms on admission | 8 | 3 | |
Admission diagnosis | COVID-19 | COVID-19 | |
Comorbidities | Arterial Hypertension | None known | |
Day 1 symptoms | Headache, myalgia, altralgia, fever | Fever, dry cough, asthenia, adynamia | |
Respiratory symptoms | 48 hours after initial symptoms | From the 1st day of the onset of symptoms | |
Day 1 hospitalization | Suspicion and sampling NS1/IgM DENV | Suspicion and sampling RT-PCR COVID-19 | |
Leukocytes/mm3 | 3100 | 2180 | 4000–11,000 |
Lymphocytes/mm3 | 410 (10%) | 296.48 (13,6%) | 20–40% |
Hemoglobin (mg/dL) | 13 | 11.8 | 13–15 |
Hematocrit (%) | 48 | 45 | 30–45 |
Platelet/mm3 | 47,000 | 70,000 | 150,000–450,000 |
AST (U/L) | 48 | 64 | < 40 |
ALT (U/L) | 25 | 33 | < 40 |
D-Dimer (ng/mL) | 639 | 1475 | < 500 |
CRP (mg/dL) | 9 | 49.8 | < 1 |
LDH (U/L) | 494 | 989 | < 150 |
Serum creatinine (mg/dL) | 0.75 | 1.9 | 0.5–1 |
Day 3 | NS1/IgM positive (9 days of symptoms) | RT-PCR positive for COVID 19 | |
Day 4 | RT-PCR positive for COVID 19 | Persistent thrombocytopenia suspected DENV ELISA and collection of RT-PCR sample collection | |
Day 5 | RT–PCR DENV positive for DENV serotype 2 | ELISA positive for DENV. RT–PCR DENV positive for DENV serotype 3 | |
Clinical course and outcome | Patient progressed to ventilatory failure requiring prolonged invasive mechanical ventilation, needed for tracheostomy, transferred to a chronic care center | Patient with acute ventilatory failure, requiring invasive mechanical ventilation, with progressive clinical deterioration and multiple organ failure, that eventually led to death | |
Final diagnosis | DENV2 and SARS-CoV-2 co-infection | DENV3 and SARS-CoV-2 co-infection |