Immunoinformatics approach for multi-epitope vaccine design against structural proteins and ORF1a polyprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Table 1 Cytotoxic T-cell lymphocyte predicted epitopes of selected proteins based on antigenicity, toxicity, and immunogenicity

Protein	Peptide	Length	Antigenicity^a	Toxicity^b	Immunogenicity^c
S	QLTPTWRVY	9 mer	1.2119	Non-toxic	0.31555
	VLPFNDGVY	9 mer	0.4642	Non-toxic	0.1815
	WTAGAAAYY	9 mer	0.6306	Non-toxic	0.15259
	CNDPFLGVY	9 mer	0.4295	Non-toxic	0.15232
M	AGDSGFAAY	9 mer	0.9095	Non-toxic	0.03981
N	LSPRWYFYY	9 mer	1.2832	Non-toxic	0.35734
N	DLSPRWYFY	9 mer	1.7645	Non-toxic	0.25933
ORF1a	VSDIDITFL	9 mer	2.2906	Non-toxic	0.38916
	TLRVEAFEY	9 mer	0.4509	Non-toxic	0.34997
	HVGEIPVAY	9 mer	0.6413	Non-toxic	0.28861
	STNVTIATY	9 mer	0.7143	Non-toxic	0.25822
	LVSDIDITF	9 mer	1.7830	Non-toxic	0.2541
	NGDVVAIDY	9 mer	0.6625	Non-toxic	0.25105
	VVDYGARFY	9 mer	0.4908	Non-toxic	0.18539
	GTDPYEDFQ	9 mer	0.5315	Non-toxic	0.17381
	VTNNTFTLK	9 mer	0.7146	Non-toxic	0.16567
	ETSWQTGDF	9 mer	1.3140	Non-toxic	0.13449
	FMGRIRSVY	9 mer	0.5212	Non-toxic	0.1259
	VVVNAANVY	9 mer	0.4078	Non-toxic	0.10048

ISSN: 2055-0936