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Table 1 Summary of common forms of mercury, their sources of exposure, major symptoms, and method of excretion with biological half-life

From: The “wing-heeled” traveler

Form

Source(s)

Absorption

Target Organ(s)

Signs/Symptoms

Major Excretory Pathway

Approximate

Biological Half-Life

Elemental (Hg0)

Occupational

Dental Amalgam

Inhalation (vapour)

CNS, PNS, Kidney

Insomnia, anxiety, tremor, peripheral neuropathy, nephropathy

Urine and Feces

60 days

Inorganic Hg Salts

Topical antiseptics, cosmetics through disrupted skin/epithelium

Ingestion, dermal

Gut, Kidney

Nausea, vomiting nephropathy

Urine and Feces

40 days (typical range 1–3 months)

Methyl Hg

Diet (fish)

Ingestion

CNS

Perioral paresthesia, constriction of visual fields, dysarthria, ataxia, impaired hearing, tremor

Feces

40–70 days

Ethyl Hg

Thimerosal containing vaccines

Parenteral

CNS, Kidney

Ataxia, paraparesis, deafness, constricted visual fields

Feces

7–20 days

  1. * Adapted from Clarkson TW, Magos L, Myers GJ. The toxicology of mercury – current exposures and clinical manifestations. N. Engl. J. Med. 2003;349:1731–7