TY - JOUR AU - Masood, Kiran Iqbal AU - Jamil, Bushra AU - Akber, Alnoor AU - Hassan, Maheen AU - Islam, Muniba AU - Hasan, Zahra PY - 2020 DA - 2020/02/19 TI - Testing for Mycobacterium tuberculosis infection using the QuantiFERON-TB GOLD assay in patients with comorbid conditions in a tertiary care endemic setting JO - Tropical Diseases, Travel Medicine and Vaccines SP - 3 VL - 6 IS - 1 AB - There were 10 million new cases of tuberculosis (TB) in 2017. To eliminate TB, it is necessary to diagnose active TB and latent tuberculosis infection (LTBI). Diagnosis of paucibacillary disease and in extrapulmonary TB (EPTB) remains challenging; low mycobacterial load can be missed by microbiological or molecular based confirmation; EPTB, can be misdiagnosed due to absence of site specific specimens for testing. Interferon gamma release assays (IGRA) use T cell-based Interferon-gamma (IFN-γ) to identify infection with M. tuberculosis (MTB) but cannot discriminate between active and LTBI. We investigated how IGRA was being used in a high burden low resource setting. SN - 2055-0936 UR - https://doi.org/10.1186/s40794-020-0102-z DO - 10.1186/s40794-020-0102-z ID - Masood2020 ER -