From: Imported visceral leishmaniasis and immunosuppression in seven Norwegian patients
Case no | Sex | Age | Microscopy (site) | Serology | PCR (site) | Sequencing | Hemoglobin (13.4–17.0 g/dl) | Leukocyte (3.5–10.0 109/L) | Thrombocytes (145–390 109/L) | Treatment – total cumulative doses of AmB/L-AmB | Outcome |
---|---|---|---|---|---|---|---|---|---|---|---|
Patient 1 | M | 66 | Positive (skin ulcer) | Positive | Positive (bone marrow) | L.infantum | 8.8 | 1.4 | 165 | 2350 mg(26 mg/kg) | Cured |
Patient 2 | M | 78 | Positive (spleen) | Positive | NA | NA | 9.3 | 1.0 | 20 | 1740 mga(23 mg/kg) | Cured |
Patient 3 | M | 79 | Positive (bone marrow) | Positive | NA | NA | 8.6 | 1.0 | 15 | 1800 mg(20 mg/kg) | Cured. Relapse after 17 months, recovery after re-treatment L-AmB 2000 mg. Died two years later of unknown cause |
Patient 4 | M | 57 | Positive (spleen aspirate) | Positive | Positive (blood) | L.infantum | 7.6 | 0.9 | 105 | 1400 mg21 mg/kg | Cured |
Patient 5 | M | 41 | Positive (bone marrow) | NA | Positive (blood) | L.infantum | 8.5 | 1.8 | 95 | 2040 mg (29 mg/kg) | Cured. Relapse after 3 months, recovery after re-treatment L-AmB 1400 mg. FU = 19 months |
Patient 6 | M | 83 | Positive (spleen aspirate) | Positive | Positive (spleen and blood) | L.infantum | 10.0 | 1.6 | 110 | 3300 mg (37 mg/kg) | Cured |
Patient 7 | F | 46 | No parasites seen (spleen aspirate) | NA | Positive (spleen) | L.infantum | 9.8 | 1.3 | 61 | 1760 mg (21 mg/kg) | Cured |