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Table 2 Demographic (A), genotyping (B), and drug resistance (C) data of eight Mycobacterium tuberculosis strains of genotypes SIT149:A and SIT149:L

From: Line-probe assay and molecular typing reveal a potential drug resistant clone of Mycobacterium tuberculosis in Ethiopia

A.

Sample ID

BTBH003

BTBS101

BTBS119

BTBH455

BTBS785

BTBS341

BTBS571

BTBH946

Site

Woldiya

Gondar

Fiche

Woldiya

Fiche

Butajira

Woldiya

Butajira

Isolation year

2006

2009

2009

2007

2010

2009

2010

2009

B.

Genotypea

A

A

A

A

A

L

L

L

580

2

2

2

2

2

2

2

2

2996

1

1

1

1

1

1

1

1

802

2

2

2

2

2

2

2

2

960

5

5

5

5

5

5

5

5

1644

1

1

1

1

1

1

1

1

3192

3

3

3

3

3

3

3

3

424

1

1

1

1

1

1

1

1

577

4

4

4

4

4

4

4

4

2165

3

3

3

3

3

3

3

3

2401

5

5

5

5

5

4

4

4

3690

3

3

3

3

3

3

3

3

4156

3

3

3

3

3

3

3

3

2163b

1

1

1

1

1

1

1

1

1955

3

3

3

3

3

3

3

3

4052

7

7

7

7

7

7

7

7

154

2

2

2

2

2

2

2

2

2531

5

5

5

5

5

5

5

5

4348

2

2

2

2

2

2

2

2

2059

2

2

2

2

2

2

2

2

2687

1

1

1

1

1

1

1

1

3007

3

3

3

3

3

3

3

3

2347

4

4

4

4

4

4

4

4

2461

2

2

2

2

2

2

2

2

3171

3

3

3

3

3

3

3

3

C.

RMPb

R

R

S

R

R

S

R

S

INHb

R

R

R

R

R

R

R

R

rpoB WT1

+

+

+

+

+

+

+

+

rpoB WT2

+

+

+

+

+

+

+

+

rpoB WT3

+

+

+

+

+

+

+

+

rpoB WT4

+

+

+

+

+

+

+

+

rpoB WT5

+

+

+

+

+

+

+

+

rpoB WT6

+

+

+

+

+

+

+

+

rpoB WT7

+

+

+

+

+

+

+c

+

rpoB WT8

+

+

+c

+

rpoB Mut1

rpoB Mut2A

+

rpoB Mut2B

+

rpoB Mut3

+

+

+

+

+

inhA WT1

+

+

+

+

+

+c

inhA WT2

+

+

+

+

+

+

+c

+

inhA Mut1

+

+

inhA Mut2

+

inhA Mut3A

inhA Mut3B

+

katG WT

katG Mut1

+

+

+

+

+

katG Mut 2

  1. Loci with variability between isolates with regards to genotype and drug resistance are underlined and in italic
  2. aGenotype refers to Spoligotype SIT149 stratified by number of repeats in respective MIRU-VNTR locus shown here (580; 2996; 802; 960; 1644; 3192; 424; 577; 2165; 2401; 3690; 4156; 2163b; 1955; 4052; 154; 2531; 4348; 2059; 2687; 3007; 2347; 2461; 3171). A, genotype SIT149:A; L, genotype SIT149:L
  3. bS drug susceptible, R drug resistant, + positive hybridization, − negative hybridisation
  4. cPositive hybridisation of wild type probe despite hybridisation to a corresponding mutation; indication of dual infection or cross-contamination of sample