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Table 2 Demographic (A), genotyping (B), and drug resistance (C) data of eight Mycobacterium tuberculosis strains of genotypes SIT149:A and SIT149:L

From: Line-probe assay and molecular typing reveal a potential drug resistant clone of Mycobacterium tuberculosis in Ethiopia

A. Sample ID BTBH003 BTBS101 BTBS119 BTBH455 BTBS785 BTBS341 BTBS571 BTBH946
Site Woldiya Gondar Fiche Woldiya Fiche Butajira Woldiya Butajira
Isolation year 2006 2009 2009 2007 2010 2009 2010 2009
B. Genotypea A A A A A L L L
580 2 2 2 2 2 2 2 2
2996 1 1 1 1 1 1 1 1
802 2 2 2 2 2 2 2 2
960 5 5 5 5 5 5 5 5
1644 1 1 1 1 1 1 1 1
3192 3 3 3 3 3 3 3 3
424 1 1 1 1 1 1 1 1
577 4 4 4 4 4 4 4 4
2165 3 3 3 3 3 3 3 3
2401 5 5 5 5 5 4 4 4
3690 3 3 3 3 3 3 3 3
4156 3 3 3 3 3 3 3 3
2163b 1 1 1 1 1 1 1 1
1955 3 3 3 3 3 3 3 3
4052 7 7 7 7 7 7 7 7
154 2 2 2 2 2 2 2 2
2531 5 5 5 5 5 5 5 5
4348 2 2 2 2 2 2 2 2
2059 2 2 2 2 2 2 2 2
2687 1 1 1 1 1 1 1 1
3007 3 3 3 3 3 3 3 3
2347 4 4 4 4 4 4 4 4
2461 2 2 2 2 2 2 2 2
3171 3 3 3 3 3 3 3 3
C. RMPb R R S R R S R S
INHb R R R R R R R R
rpoB WT1 + + + + + + + +
rpoB WT2 + + + + + + + +
rpoB WT3 + + + + + + + +
rpoB WT4 + + + + + + + +
rpoB WT5 + + + + + + + +
rpoB WT6 + + + + + + + +
rpoB WT7 + + + + + + +c +
rpoB WT8 + + +c +
rpoB Mut1
rpoB Mut2A +
rpoB Mut2B +
rpoB Mut3 + + + + +
inhA WT1 + + + + + +c
inhA WT2 + + + + + + +c +
inhA Mut1 + +
inhA Mut2 +
inhA Mut3A
inhA Mut3B +
katG WT
katG Mut1 + + + + +
katG Mut 2
  1. Loci with variability between isolates with regards to genotype and drug resistance are underlined and in italic
  2. aGenotype refers to Spoligotype SIT149 stratified by number of repeats in respective MIRU-VNTR locus shown here (580; 2996; 802; 960; 1644; 3192; 424; 577; 2165; 2401; 3690; 4156; 2163b; 1955; 4052; 154; 2531; 4348; 2059; 2687; 3007; 2347; 2461; 3171). A, genotype SIT149:A; L, genotype SIT149:L
  3. bS drug susceptible, R drug resistant, + positive hybridization, − negative hybridisation
  4. cPositive hybridisation of wild type probe despite hybridisation to a corresponding mutation; indication of dual infection or cross-contamination of sample