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Table 1 Selected publications showing prophylactic antibiotic use and its protection rate against TD in chronological order from oldest to newest

From: A review of antibiotic prophylaxis for traveler’s diarrhea: past to present

Publication year Drug name Participants studied Protection rate (%) Reference
1960s
 1962 Neomycin 305 32 [39]
 1962 Phthalylsulfathiazole 336 50 [39]
1970s
 1978 Doxycycline 39 86 [43]
 1979 Doxycycline 50 83 [44]
1980s
 1981 Doxycycline 46 27 [45]
 1981 Erythromycin 48 71 [54]
 1982 TMP/SMX 147 71 [49]
 1983 TMP/SMX 87 95 [50]
 1983 Mecillinam 74 75 [56]
 1983 Doxycycline 145 81 [48]
 1984 Doxycycline 63 68 [46]
 1984 Doxycycline 44 59 [47]
 1985 Mecillinam 32 66 [57]
 1985 Bicozamycin 30 100 [59]
 1986 Norfloxacin 115 88 [63]
 1987 Norfloxacin 115 70 [64]
 1989 Ciprofloxacin 59 94 [61]
1990s
 1990 Norfloxacin 222 93 [65]
 1994 Ciprofloxacin 21 100 [62]
 1994 Ciprofloxacin 99 84 [51]
 1994 TMP/SMX 87 51 [51]
 1996 Azithromycin 231 81 [72]
2000s
 2005 Rifaximin 210 72 [33]
 2010 Rifaximin 95 67 [34]
 2010 Rifaximin 201 58 [35]
 2011 Rifaximin 98 28 [32]
 2013 Rifaximin 239 48 [36]