A review of antibiotic prophylaxis for traveler’s diarrhea: past to present

Table 1 Selected publications showing prophylactic antibiotic use and its protection rate against TD in chronological order from oldest to newest

Publication year	Drug name	Participants studied	Protection rate (%)	Reference
1960s
1962	Neomycin	305	32	[39]
1962	Phthalylsulfathiazole	336	50	[39]
1970s
1978	Doxycycline	39	86	[43]
1979	Doxycycline	50	83	[44]
1980s
1981	Doxycycline	46	27	[45]
1981	Erythromycin	48	71	[54]
1982	TMP/SMX	147	71	[49]
1983	TMP/SMX	87	95	[50]
1983	Mecillinam	74	75	[56]
1983	Doxycycline	145	81	[48]
1984	Doxycycline	63	68	[46]
1984	Doxycycline	44	59	[47]
1985	Mecillinam	32	66	[57]
1985	Bicozamycin	30	100	[59]
1986	Norfloxacin	115	88	[63]
1987	Norfloxacin	115	70	[64]
1989	Ciprofloxacin	59	94	[61]
1990s
1990	Norfloxacin	222	93	[65]
1994	Ciprofloxacin	21	100	[62]
1994	Ciprofloxacin	99	84	[51]
1994	TMP/SMX	87	51	[51]
1996	Azithromycin	231	81	[72]
2000s
2005	Rifaximin	210	72	[33]
2010	Rifaximin	95	67	[34]
2010	Rifaximin	201	58	[35]
2011	Rifaximin	98	28	[32]
2013	Rifaximin	239	48	[36]

ISSN: 2055-0936