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Table 1 Summary of previously reported Zika congenital syndrome fetal ultrasound abnormalities

From: Zika virus infection in a pregnant Canadian traveler with congenital fetal malformations noted by ultrasonography at 14-weeks gestation

Gestation at First Abnormal Ultrasound (weeks) Study Author, Year Country of Infection Gestation at Infection Ultrasound Findings Outcome
18 Sarno et al., 2016 [11] Brazil NR Microcephaly, hydranencephaly, intracranial calcifications, destructive lesions of posterior fossa. Hydrothorax, ascites, subcutaneous edema Fetal demise at 32 weeks
19 Driggers et al., 2016 [12] Unknown (Guatemala, Mexico or Belize) 11 weeks Possible intraventricular haemorrhage, corpus callosum agenesis TA at 21 weeks
19 Pomar et al., 2017 [13] French Guiana First trimester Severe microcephaly, cerebral hypoplasia Delivery at 32 weeks
19.3 Cortes et al., 2018 [14] Colombia NR Enlarged subarachnoid space, decreased brain volume, ventriculomegaly, malformations in cortical development, simplified gyral pattern, hypoplasic corpus callosum Unknown
20 Pomar et al., 2017 [13] French Guiana First trimester Cystic dilation of the cisterna magna, cortical hyperechogenicity, vermian hypoplasia, pericallosal echogenicity Delivery at 38 weeks
21 Besnard et al., 2016 [15] French Polynesia First trimester Microcephaly, parenchymal calcifications, ventriculomegaly, absent corpus callosum, absent cavum septi pellucidi TA at unknown weeks
22 Pomar et al., 2017 [13] French Guiana First trimester Periventricular hyperechogenicity, irregular ventricular walls, parenchymal and periventricular calcifications Delivery at 41 weeks
22 Carvalho et al., 2016 [16] Brazil 9 weeks Microcephaly, parenchymal and ocular calcifications, Dandy Walker malformation, arthrogryposis Fetal demise, CS at 37 weeks
22 Besnard et al., 2016 [15] French Polynesia First trimester Microcephaly, parenchymal calcifications, ventriculomegaly, absent corpus callosum, absent of cavum septi pellucidi, enlarged pericerebral space TA at unknown weeks
24 Carvalho et al., 2016 [16] Brazil 5 weeks Dandy Walker malformation, fetal growth restriction, arthrogryposis. Fetal demise, CS 38.3 weeks
25.3 Cortes et al., 2018 [14] Colombia NR Enlarged subarachnoid space, decreased brain volume, ventriculomegaly, malformations in cortical development, simplified gyral pattern, hypoplasic corpus callosum NR
26.5 Cortes et al., 2018 [14] Colombia NR Dandy Walker cerebella malformation NR
27 Carvalho et al., 2016 [16] Brazil 11 weeks Microcephaly, ventriculomegaly bilaterally, parenchymal calcifications, increased subarachnoid space CS delivery of live infant at 38 weeks
27 Cortes et al., 2018 [14] Colombia NR Decreased brain volume, ventriculomegaly, simplified gyral pattern, hypoplastic corpus callosum NR
28 Pomar et al., 2017 [13] French Guiana Second trimester Severe ventriculomegaly with irregular ventricular walls, thin hypoplastic corpus callosum TA at 29 weeks
28 Carvalho et al., 2016 [16] Brazil 8 weeks Microcephaly, ventriculomegaly, parenchymal calcification, and oligohydraminios SVD of live infant at 39 weeks
28 Carvalho et al., 2016 [16] Brazil 8 weeks Microcephaly, ventriculomegaly, parenchymal calcifications, cortical atrophy and cerebellar hypoplasia. SVD of live infant at 39 weeks
28 Carvalho et al., 2016 [16] Brazil 10 weeks Microcephaly, left ventriculomegaly, increase cisterna magna. CS delivery of live infant at 40 weeks
28.2 Cortes et al., 2018 [14] Colombia NR Enlarged subarachnoid space, decreased brain volume, ventriculomegaly, malformations in cortical development, simplified gyral pattern, hypoplasic corpus callosum NR
29 Pomar et al., 2017 [13] French Guiana Second trimester Lentostriatal vasculopathy Delivery at 39 weeks
29 Carvalho et al., 2016 [16] Brazil 16 weeks Microcephaly, periventricular calcifications, megacisterna magna, cerebellar vermis hypoplasia. Thymic and liver calcifications, fetal growth restriction Stillbirth, labour induced
29 Mlakar et al., 2016 [17] Brazil 13 weeks Microcephaly, parenchymal calcifications. Fetal growth restriction, placental calcifications. TA at 32 weeks
29.2 Besnard et al., 2016 [15] French Polynesia NR Microcephaly, parenchymal calcifications, placental microcalcifications, ventriculomegaly, occipital pseudo-cyst, absent corpus callosum, absent cavum septi pellucidi, enlarged pericerebral space TA at unknown weeks
29.2 Oliveira Melo et al., 2016 [18] Brazil NR Ventriculomegaly, corpus callosum not visualized, thalami not developed, thin pons and brainstem, non-homogeneous small mass seen at position of basal ganglia, lateral ventricles and fourth ventricle calcifications. Cataracts bilaterally, intraocular calcifications and one eye smaller in size than the other Unknown
29.3 Besnard et al., 2016 [15] French Polynesia First trimester Microcephaly, ventriculomegaly, occipital pseudo-cyst, enlarged pericerebral space TA at unknown weeks
30.1 Oliveira Melo et al., 2016 [18] Brazil NR Brain atrophy, calcifications in frontal lobes including caudate, lentostriatal vessels and cerebellum. Corpus callosal and vermian dysgenesis, enlarged cisterna magna. Unknown
31 Carvalho et al., 2016 [16] Brazil 8 weeks Microcephaly, parenchymal and cerebellar calcifications. SVD of live infant at 40 weeks
31 Carvalho et al., 2016 [16] Brazil 9 weeks Microcephaly, parenchymal and cerebellar calcifications, brain atrophy, cerebellar hypoplasia. Right clubfoot, nuchal skin wrinkling, increase cisterna magna, fetal growth restriction. CS delivery of live infant at 39 weeks
31 Carvalho et al., 2016 [16] Brazil NR Polyhydramnios, parenchymal and cerebellar calcifications. Hepatomegaly, hyperflexion of fingers, and hyperechogenicity of aortic valve, mitral valve and aortic root. SVD of live infant at 38 weeks
31 Carvalho et al., 2016 [13] Brazil NR Microcephaly, ventriculomegaly, parenchymal calcifications CS delivery of live infant at 39 weeks
33 Cortes et al., 2018 [14] Colombia NR Enlarged subarachnoid space, decreased brain volume, ventriculomegaly, dysgenetic corpus callosum NR
34.2 Cortes et al., 2018 [14] Colombia NR Enlarged subarachnoid space, decreased brain volume, ventriculomegaly, malformations in cortical development, simplified gyral pattern, dysgenetic corpus callosum NR
35 Carvalho et al., 2016 [16] Brazil NR Microcephaly, parenchymal and cerebellar calcifications, ventriculomegaly CS delivery of live infant at 39 weeks
36 Carvalho et al., 2016 [16] Brazil NR Microcephaly. Right clubfoot, fetal growth restriction Fetal demise, CS at 38 weeks
36 Carvalho et al., 2016 [16] Brazil 11 weeks Microcephaly CS delivery of live infant at 40 weeks
37 Pomar et al., 2017 [13] French Guiana Second trimester Microcephaly, callosal hypoplasia, gyration anomalies Delivery at 39 weeks
37 Carvalho et al., 2016 [16] Brazil 8 weeks Microcephaly, parenchymal and cerebellar calcifications, left ventriculomegaly SVD of live infant at 39 weeks
38 Carvalho et al., 2016 [16] Brazil 10 weeks Microcephaly, periventricular and parenchymal calcifications, ventriculomegaly. Fetal growth restriction. CS delivery of live infant at 39 weeks
38 Carvalho et al., 2016 [16] Brazil 16 weeks Microcephaly, parenchymal and periventricular calcifications, left ventriculomegaly. Fetal growth restriction, oligohydramnios CS delivery of live infant at 39 weeks
38 Carvalho et al., 2016 [16] Brazil NR Microcephaly, parenchymal and cerebellar calcifications, ventriculomegaly SVD of live infant at 39 weeks
39 Carvalho et al., 2016 [16] Brazil NR Microcephaly, parenchymal calcifications. SVD of live infant at 39 weeks
NR Pomar et al., 2017 [13] French Guiana First trimester Microcephaly, cerebellar hypoplasia, ventriculomegaly with irregular ventricular walls, periventricular hyperechogenicity, callosal hypoplasia with calcifications, parenchymal califications NR
NR Pomar et al., 2017 [13] French Guiana Second trimester Parenchymal hyperechogenicity Fetal demise at 40 weeks
NR Pomar et al., 2017 [13] French Guiana First trimester Microcephaly Fetal demise at 19 weeks
  1. NR not reported, SVD spontaneous vaginal delivery, CS caesarean section, TA therapeutic abortion