Table 1 A summary of various experiments using the Salivary Gland as an immunization site

Formalized

S. mutans

++++

++++

[18]

NHP

SGid > SC; Greater IgA and IgG seen with SGid imzn than with SC imzn.

Formalized

S. mutans

+++

+++

[21]

NHP

Greater IgA seen with SGid imzn than with SC imzn.

Formalized

S. mutans

++++

++++

[19]

NHP

SGid imzn resulted in semi-protection against a S. mutans challenge.

Formalized

S. mutans

++++

+++

[20]

NHP

SGid immunization was strain specific.

Bovine serum albumin

++^a

++^a

[13]

Rats

SGid; Moderate salivary and systemic antibody responses reported

Bovine serum albumin

++^a

+^a

[14]

Rats

Multiple SGid BSA imzns are followed by systemic antibodies.

MCMV, tcMCMV

n.a.

++++

[33]

Mice

SGig imzn resulted in protection from viremia; IP imzn did not.

MCMV, tcMCMV

+++

+++

[7]

Mice

SGig > IP; Greater IgA and IgG seen with SGig imzn than with IP imzn.

Adenovirus

+++

++++

[15]

Rats

SGid; Repeated pre-exposure to inactivated adenovirus induced immune tolerance.

tcMCMV

+++

++++

[34]

Mice

SGid imzn resulted in protection from a lethal challenge.

pDNA: fimbriae from P. ginigivalis

++++

+++

[23]

Mice

TSG > IM; Greater IgA seen with TSG imzn, than with IM imzn. TSG and IM imzns resulted in equal IgG.

pDNA: influenza NP protein

n.c.

+++

[24]

Rats

SGid; Included testing of two adjuvants.

pDNA: NP protein, hGH,

gp120, anthrax PA

++++

++++

[25]

Rats

SGid > IM; Greater IgA and IgG seen with SGid imzn than with IM imzn. SG imzn protected from a lethal challenge; IM imzn did not; distal mucosal response seen.

pDNA: gp120

+++

+++

[27]

Rats, dogs

SGid > IM (ASCs from Peyer’s patches); distal mucosal IgA response seen in lungs.