|Whole cell pertussis vaccine (wP)||Acellular pertussis vaccine (aP)|
-Blocked disease and infection to a much higher extent than aP|
-Probably did this by blocking carriage (though studies were never done to prove that hypothesis).
-Blocked disease but did not block infection.|
-Experimentally do not block carriage and permit transmission from asymptomatic to vaccine naïve animals. This observation closely mimics the cocooning strategy, and suggests a reason why it had failed to perform as anticipated.
|-Epidemiologically appears to offer herd effect (though not to a level sufficient to halt transmission entirely).||-Epidemiologically offers minimal or no herd effect.|
|-Induces robust mucosal immunity.||-Seemingly absent of mucosal immunity induction.|
|-Induces robust Th17 responses.||-Induces Th2 response.|