From: The Pertussis resurgence: putting together the pieces of the puzzle
Whole cell pertussis vaccine (wP) | Acellular pertussis vaccine (aP) |
---|---|
-Blocked disease and infection to a much higher extent than aP -Probably did this by blocking carriage (though studies were never done to prove that hypothesis). | -Blocked disease but did not block infection. -Experimentally do not block carriage and permit transmission from asymptomatic to vaccine naïve animals. This observation closely mimics the cocooning strategy, and suggests a reason why it had failed to perform as anticipated. |
-Epidemiologically appears to offer herd effect (though not to a level sufficient to halt transmission entirely). | -Epidemiologically offers minimal or no herd effect. |
-Induces robust mucosal immunity. | -Seemingly absent of mucosal immunity induction. |
-Induces robust Th17 responses. | -Induces Th2 response. |