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Fig. 4 | Tropical Diseases, Travel Medicine and Vaccines

Fig. 4

From: The Pertussis resurgence: putting together the pieces of the puzzle

Fig. 4

Infections from an asymptomatic vaccinated to unvaccinated animal. The first experiment showed that an unvaccinated but infected animal is capable of infecting an aP vaccinated animal. This experiment approaches this dynamic in reverse: here an aP vaccinated animal was infected with B. pertussis and then co-housed with an unvaccinated animal. Despite being asymptomatic, the aP vaccinated animal quickly infected the vaccine naïve control animal, who developed clinical disease as well as nasopharyngeal carriage showing that infection had occurred. This proved that, despite being symptom free, aP vaccinated animals can become infected with pertussis, and are able to transmit to unvaccinated animals. In other words, aP vaccination only prevented clinical disease, but did not prevent animals from being infectious and contributing to chains of transmission

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