From: Are you PEPped and PrEPped for travel? Risk mitigation of HIV infection for travelers
Medication | Dose (mg) | Frequency | Comments | Guidelines | ||
---|---|---|---|---|---|---|
Pre-Exposure Prophylaxis (PrEP) | CDC | WHO | IAS | |||
TDF + FTC | 300/ 200 | Daily | TDF- Nausea, flatulence FTC- rash, headache; distinguish from the treatment co-formulation with efavirenz | X | X | X |
TDF | 300 | Daily | Not recommended alone in the US; whether in combination or alone, avoid in patients with renal injury or bone disease | Â | X | Â |
non-occupational Post-Exposure Prophylaxis (nPEP) | CDC | WHO | Â | |||
TDF + FTC + RAL | 300/ 200 400 | Daily Twice daily | RAL- Mild hepatitis is common, and hypersensitivity, severe skin reactions have been reported though more common side effects include fatigue, headache, dizziness, nausea and insomnia Alternative recommendation for health adults and adolescents is TDF + FTC + DRV. In renal dysfunction, ZDV + 3TC + either RAL or DTG is recommended | X |  |  |
TDF + FTC + either LPV/r or ATV/r | 300/ 200 Varies | Daily | Alternatives for the 3rd drug on the TDF + FTC backbone include RAL, DRV/r, EFV |  | X |  |
occupational Post-Exposure Prophylaxis (oPEP) | PHS | WHO | Â | |||
TDF + FTC + RAL | 300/ 200 400 | Daily Twice daily | The core recommendation is to take 3 or more tolerable drugs; listed alternatives for TDF + FTC include ZDV + 3TC; listed alternatives for RAL include DRV/r, ETR, RPV, ATZ/r, LPV/r; listed alternative for all is a single co-formulation of four ART medications (TDF, FTC, EVG, cobicistat) | X |  |  |
TDF + FTC + either LPV/r or ATV/r | 300/ 200 Varies | Daily | Alternatives for the 3rd drug on the TDF + FTC backbone include RAL, DRV/r, EFV WHO guidelines do not distinguish nPEP and oPEP |  | X |  |